Abstract #2024
Hippocampal disconnection predicts cognitive impairment in patients with cerebrovascular disease
Dewen Meng 1 , Akram A. Hosseini 1 , Richard J. Simpson 1 , Robert A. Dineen 1 , and Dorothee P. Auer 1
1
Radiological Sciences,Division of Clinical
Neurosciences, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
Cognitive impairment is common in patients with
cerebrovascular disease. The mechanisms underlying
vascular cognitive impairment (VCI) have not been well
established. Resting-state functional MRI has provided
new insights on the functional connectivity (fc) of
brain. The aim of this study was to assess fc
abnormalities as potential neural substrate of cognitive
impairment in patients with recently symptomatic carotid
artery disease.Our findings show that VCI results from
long range disconnection of the left hippocampus fc and
default mode network, suggesting that fc assessed by
resting-state fMRI has the potential to become a
diagnostic marker that may also be useful for the
assessment of treatment and rehabilitation.
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