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Abstract #2022

Remote Ischaemic Post Conditioning is Neuroprotective in White Matter in a Piglet Model of Perinatal Asphyxia: an MRS and Immunohistochemistry Study

Alan Bainbridge 1 , Mojgan Ezzati 2 , Kevin Broad 2 , Go Kawano 2 , Aaron Oliver-Taylor 2 , Igor Fierens 2 , Jamshid Rostami 2 , Jane Hassell 2 , Ilias Tachsidis 3 , Pierre Gressens 4 , Mariya Hristova 5 , Kate Bennett 2 , Magdalena Sokolska 6 , Price David 6 , Bobbi Fleiss 4 , Derek Yellon 7 , Derek J Hausenloy 7 , Xavier Golay 8 , and Nicola J Robertson 2

1 Medical Physics, UCLH NHS Foundation trust, London, United Kingdom, 2 Institute for Women's Health, University College London, United Kingdom, 3 Medical Physics, University College London, United Kingdom, 4 Centre for the Developing Brain, Institute of Reproductive and Developmental Biology, Imperial College, United Kingdom, 5 Wellcome Centre for Imaging Neuroscience, University College London, United Kingdom, 6 Medical Physics, UCLH NHS Foundation trust, United Kingdom, 7 The Hatter Cardiovascular Institute, University College London, United Kingdom, 8 Institute of Neurology, University College London, United Kingdom

Neonatal encephalopathy is associated with high mortality and morbidity rates worldwide. There is an unmet need to develop novel, non-invasive approaches, which can be used alone or in combination with hypothermia to augment neuroprotection. The aim of this study was to assess whether hind limb remote IPostC after transient hypoxia-ischaemia (HI) is neuroprotective based on 1H and 31P MRS cerebral biomarkers and immunohistochemistry in a piglet model of perinatal asphyxia. Remote IPostC was neuroprotective based on reduced WM Lac/NAA at 48h and reduced TUNEL positive cells in WM. Whole brain 31P MRS NTP/epp was preserved with remote IPostC.

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