Abstract #1988
Differing patterns of white matter connectivity in Autism Spectrum Disorders versus Sensory Processing Disorders
Yishin Chang 1 , Julia P. Owen 1 , Shivani Desai 2 , Emily Fourie 2 , Susanna Hill 2 , Anne Arnett 2 , Julia Harris 2 , Elysa Marco 2 , and Pratik Mukherjee 1
1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco,
California, United States,
2
Department
of Neurology, University of California, San Francisco,
California, United States
Over 90% of children with Autism Spectrum Disorders (ASD)
demonstrate atypical sensory behaviors. However, there
are children with sensory processing differences (SPD)
who do not meet other criteria for ASD diagnosis. We use
probabilistic diffusion fiber tractography to compare
the white matter connectivity of children with ASD and
SPD to neurotypical children. Both the ASD and SPD
groups demonstrate abnormal connectivity in sensory
processing pathways, while the ASD group alone
demonstrates abnormal connectivity in tracts thought to
subserve social and emotional processing. These
observations help elucidate the roles of specific neural
circuits in neurodevelopmental disorders.
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