Abstract #1989
Cerebral Blood Flow Change in Late-life Depression: An ASL MRI Study.
Mu-Lan Jen 1 , Che-Min Lin 2 , Jasin Wong 1 , Shwu-Hua Lee 2 , Yau-Yau Wai 1,3 , and Ho-Ling Liu 1,3
1
Department of Medical Imaging and
Radiological Sciences, Chang Gung University, Taoyuan,
Taiwan,
2
Department
of Psychiatry, Chang Gung Memorial Hospital, Taoyuan,
Taiwan,
3
Department
of Medical Imaging and Intervention, Chang Gung Memorial
Hospital, Taoyuan, Taiwan
The purpose of this study was to evaluate the
whole-brain cerebral blood flow (CBF) change in
late-life depression (LLD) using voxelwise analysis.
Twenty-one LLD patients and seventeen elder controls
underwent background suppressed 3D pseudo-continuous
arterial spin labeling (PCASL) MRI scans. This study
showed that significant (P<0.01, corrected)
hypoperfusion in LLD in prefrontal cortex included left
rectal, subcallosal and medial frontal gyrus. Also, CBF
tend to be lower in LLD in the bilateral anterior
cingulate gyrus.
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