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Abstract #1987

Disrupted effective connectivity in first-episode patients with major depressive disorder

zhan feng 1 , manli huang 2 , and hong yang 2

1 radiology, The First Affiliated Hospital of College of Medicine, Zhejiang University, hangzhou, zhejiang, China, 2 The First Affiliated Hospital of College of Medicine, Zhejiang University, zhejiang, China

The prefrontalClimbic network(PLN) is dysregulated in major depressive disorders(MDD),We use the Granger causality analysis to study variation of effective connectivity in PLN.The decrease of effective connectivity of prefrontal cortex proved that top-down cognitive control function reduction existed in MDD. The abnormality of effective connectivity from right insular cortex to rACC showed that there was something wrong with the SN switching function between central-executive network and default-mode networks under the resting state.These specific abnormal connectivities further supplemented the dynamic active process of PLN of MDD patients.

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