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Abstract #1965

Perfusion based functional connectivity in autism reveals hypo-perfusion and altered connectivity of the Default Mode Network associated with increased symptom severity

Kay Jann 1 , Devora Beck-Pancer 2 , Emily Kilroy 3 , Mirella Dapretto 4 , and Danny JJ Wang 1

1 Department of Neurology, University of California, Los Angeles, Los Angeles, California, United States, 2 ) Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, United States, 3 Division of Occupational Science, University of Southern California, Los Angeles, California, United States, 4 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, United States

The aim of the present study was to characterize abnormal patterns of resting state network perfusion and functional connectivity using pseudo-continuous ASL (pCASL) perfusion MRI. PCASL-based resting state networks and their baseline perfusion were identified using ICA in 12 children with autism spectrum disorder (ASD). Our results show that altered perfusion in the DMN is related to autism symptom severity. Further, reduced DMN perfusion is associated with altered connectivity of anterior and posterior DMN, suggesting an association between baseline activity within networks, their connectivity and potentially alterations in stimulus processing and/or development of clinical symptoms in ASD.

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