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Abstract #1966

White matter abnormalities in schizophrenia: A diffusion spectrum imaging study using whole brain tract-specific analysis

Yu-Jen Chen 1 , Chun-Chieh Fan 2 , Yung-Chin Hsu 1 , Yu-Chun Lo 1 , Chih-Ming Liu 3 , and Wen-Yih Isaac Tseng 1

1 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 2 Department of Cognitive Science, UC San Diego, CA, United States, 3 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taipei, Taiwan

In this study, we employed a high throughput tract-specific analysis, called tract-based automatic analysis, and a feasible statistical testing by performing threshold-free cluster enhancement (TFCE) and controlling family-wise error rate (FWER) to investigate the abnormalities of white matter tracts in schizophrenia using diffusion spectrum imaging. Our results showed consistent findings in association fibers and callosal fibers with previous studies. Furthermore, we also found many significant differences in projection fibers, such as frontal-striatal tracts and thalamo-cortical tracts. Moreover, clusters with significant difference could be discovered after applying TFCE and controlling FWER.

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