Abstract #1964
Altered anterior cingulate chemistry, blood flow, and functional connectivity in schizophrenia
Benjamin W Krause 1 , S Andrea Wijtenburg 1 , Frank Gaston 1 , Sarah Nisonger 1 , Stephanie Korenic 1 , and Laura Rowland 1,2
1
MPRC, University of Maryland School of
Medicine, Baltimore, MD, United States,
2
Russell
H. Morgan Department of Radiology and Radiological
Science, Johns Hopkins University School of Medicine,
Baltimore, MD, United States
This study combined proton magnetic resonance
spectroscopy, arterial spin labeling, and resting state
fMRI to investigate anterior cingulate neurochemistry,
regional cerebral blood flow, and functional
connectivity in participants with schizophrenia and
healthy controls. Patients had significantly lower tNAA
levels than controls. Additionally, tNAA was positively
correlated with cerebral blood flow, and this
relationship was found to be weaker in patients than
controls. We also found altered anterior cingulate
functional connectivity in patients, however, tNAA was
not significantly correlated with AC functional
connectivity in patients or controls.
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