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Abstract #1959

Dose-Dependent Influence of Short-Term Binge Ethanol Intoxication on Cerebral Neurochemical Changes in Rats Detected by Ex Vivo 1H NMR Spectroscopy

Do-Wan Lee 1 , Jung-Whan Min 2 , Jung-Hoon Lee 1,3 , Sang-Young Kim 1 , Jin-Young Jung 1 , Kyu-Ho Song 1 , and Bo-Young Choe 1

1 Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea, College of Medicine, Seoul, Seoul, Korea, 2 Department of Radiological Science, The Shingu University College of Korea, Seongnam, Seongnam, Korea, 3 Department of Radiology, Kyunghee Medical Center, Seoul, Korea

The aim of presesnt study was to assess the effects of short-term binge ethanol intoxication on cerebral metabolite changes among the controls (CNTL), the low-dose-ethanol (LDE)-exposed, and the high-dose-ethanol (HDE)-exposed rats, which were determined with the ex vivo spectra. Our results showed that the normalized tNAA, GABA, and GSH levels were significantly altered among CNTL, LDE- and HDE-exposed rats. Moreover, the 6 pairs of normalized metabolite levels were significantly correlated in the individual rat data. Our ex vivo 1H HR-MAS NMRS results suggested some novel metabolic markers for the dose-dependent influence of short-term binge ethanol intoxication in the frontal cortex.

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