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Abstract #1960

Functional and Structural Alterations Induced by Cognitive Behavioral Therapy in Social Anxiety Disorder

Yoshiyuki Hirano 1,2 , Takayuki Obata 1,2 , Chihiro Sutoh 1,2 , Daisuke Matsuzawa 1,2 , Naoki Yoshinaga 1,2 , Zhongming Liu 3 , Hiroshi Ito 2 , Hiroshi Tsuji 2 , and Eiji Shimizu 1

1 Research Center for Child Mental Development, Chiba University, Chiba, Chiba, Japan, 2 National Institute of Radiological Sciences, Chiba, Chiba, Japan, 3 School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States

We set out to investigate rsfMRI and DTI to assess the effect of cognitive behavioral therapy (CBT) on neural networks in patients with selective serotonin reuptake inhibitor (SSRI)-resistant social anxiety disorders (SAD). Increased neuronal connectivity at rest was found between the dorsal anterior cingulate cortex and striatum after 16-week CBT compared with healthy subjects. Also, decreased FA value was observed in the right anterior limb of the internal capsule after CBT. These results suggested that changes in emotional-related neural circuit by CBT exposed alterations in functional and structural MRI.

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