Abstract #1940
Tract Based Spatial Statistic reveals no differences in white matter microstructural organisation between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents
Flavio Dell'Acqua 1,2 , Wasim Khan 1,2 , David Bouls 1 , Gareth J Barker 1 , Gunther Schumann 2,3 , Simon Lovestone 2,4 , and Andrew Simmons 1,2
1
Neuroimaging, King's College London,
Institute of Psychiatry, London, United Kingdom,
2
NIHR
Biomedical Research Centre for Mental Health and
Biomedical Research Unit for Dementia, King's College
London, Institute of Psychiatry, London, United Kingdom,
3
Social,
Genetic and Developmental Psychiatry Centre, King's
College London, Institute of Psychiatry, London, United
Kingdom,
4
Old
Age Psychiatry, King's College London, Institute of
Psychiatry, London, United Kingdom
Alleles of the Apolipoprotein E (ApoE) gene are known to
modulate the genetic risk for developing late-onset
Alzheimers disease (AD). While the presence of ApoE ε4
allele is a major genetic risk factor for the
development of late onset AD, the possession of the ε2
allele has been suggested to confer a protective effect
against the disease. On a cohort of more than 500 young
healthy adolescents this TBSS study found no differences
in white matter microstructural organisation between
carriers and non-carriers of the ApoE ε4 and ε2 alleles
suggesting that effects of these alleles may emerge
later in life.
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