Abstract #1941
Phospholipid and high-energy phosphate levels in multiple brain regions in Alzheimers disease: a 3D 31 P-MRSI study
Anne Rijpma 1,2 , Marinette van der Graaf 3,4 , Olga Meulenbroek 1,2 , Rianne de Heus 1 , Marcel G.M. Olde Rikkert 1,2 , and Arend Heerschap 3
1
Geriatric Medicine, Radboud university
medical center, Nijmegen, Gelderland, Netherlands,
2
Radboud
Alzheimer Centre, Radboud university medical center,
Nijmegen, Gelderland, Netherlands,
3
Radiology,
Radboud university medical center, Nijmegen, Gelderland,
Netherlands,
4
Paediatrics,
Radboud university medical center, Nijmegen, Gelderland,
Netherlands
3D
31
P-MRSI
was performed to assess whether regional variation could
be observed in phospholipid and energy metabolism in 17
patients with mild Alzheimer Disease (AD). The results
showed significantly (P<.01) higher PE and PC content
for anterior cingulate cortex (ACC) than for retrospinal
cortex (RSC). In addition, differences in high energy
phosphates were found, with high Pi and NAD, low PCr and
ATP for the ACC, and high PCr, low ATP, Pi and NAD for
the RSC, both compared with contents obtained in the
hippocampi. These variations indicate regional
differences in phosphorus metabolism in the mild AD
brain.
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