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Abstract #1939

Neuropathologic correlates of brain white matter hyperintensity volume measured with ex-vivo MRI.

Aikaterini Kotrotsou 1 , David A. Bennett 2 , Julie A. Schneider 2 , Sue E. Leurgans 2 , and Konstantinos Arfanakis 1,2

1 Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, United States, 2 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States

The purpose of this study was to investigate the link between the total volume of brain white matter hyperintensities (WMH) and various age-related neuropathologies, in a community cohort of 264 older persons. WMH volume was measured with ex-vivo MRI on brain hemispheres from all participants. It was demonstrated that the total WMH volume was significantly associated with AD pathology and gross chronic infarcts. To our knowledge, this study is the largest MRI-pathology investigation of WMHs in a community cohort to date.

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