Neuropathologic correlates of brain white matter hyperintensity volume measured with ex-vivo MRI.
Aikaterini Kotrotsou 1 , David A. Bennett 2 , Julie A. Schneider 2 , Sue E. Leurgans 2 , and Konstantinos Arfanakis 1,2
Department of Biomedical Engineering,
Illinois Institute of Technology, Chicago, Illinois,
Alzheimer's Disease Center, Rush University Medical
Center, Chicago, Illinois, United States
The purpose of this study was to investigate the link
between the total volume of brain white matter
hyperintensities (WMH) and various age-related
neuropathologies, in a community cohort of 264 older
persons. WMH volume was measured with ex-vivo MRI on
brain hemispheres from all participants. It was
demonstrated that the total WMH volume was significantly
associated with AD pathology and gross chronic infarcts.
To our knowledge, this study is the largest
MRI-pathology investigation of WMHs in a community
cohort to date.
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