Abstract #1860
High Resolution Magnetic Resonance Elastography of Glioblastoma Multiforme
Kaspar Josche Streitberger 1,2 , Martin Rei-Zimmermann 3 , Karl-Titus Hoffmann 3 , Florian Baptist Freimann 4 , Felix Arlt 5 , Jing Guo 1 , Sebastian Hirsch 1 , Jrgen Braun 6 , and Ingolf Sack 1
1
Department of Radiology, Charit -
Universittsmedizin Berlin, Berlin, Berlin, Germany,
2
Department
of Neurology, Charit - Universittsmedizin Berlin,
Berlin, Berlin, Germany,
3
Department
of Neuroradiology, Universittsklinikum Leipzig,
Leipzig, Germany,
4
Department
of Neurosurgery, Charit - Universittsmedizin Berlin,
Berlin, Berlin, Germany,
5
Department
of Neurosurgery, Universittsklinikum Leipzig, Leipzig,
Germany,
6
Medical
Informatics, Charit - Universittsmedizin Berlin,
Berlin, Berlin, Germany
This study presents first high resolution MRE of
intracranial tumors. The reconstructed MRE parameters
|G*| and φ correspond to the magnitude and phase of the
complex shear modulus G* and therewith provide a measure
of the tumor's viscoelastic properties as encountered by
surgeons during interventions. The resolution in |G*|
and φ maps is superior to previous work enabling us for
the first time to analyze the intrinsic viscoelastic
heterogeneities of glioblastoma multiforme (GBM).
Interestingly, in 4 out of 17 cases GBM was stiffer than
healthy tissue while reduction in φ was seen in all
tumors suggesting less dissipative GBM properties.
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