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Abstract #1860

High Resolution Magnetic Resonance Elastography of Glioblastoma Multiforme

Kaspar Josche Streitberger 1,2 , Martin Rei-Zimmermann 3 , Karl-Titus Hoffmann 3 , Florian Baptist Freimann 4 , Felix Arlt 5 , Jing Guo 1 , Sebastian Hirsch 1 , Jrgen Braun 6 , and Ingolf Sack 1

1 Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 2 Department of Neurology, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 3 Department of Neuroradiology, Universittsklinikum Leipzig, Leipzig, Germany, 4 Department of Neurosurgery, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 5 Department of Neurosurgery, Universittsklinikum Leipzig, Leipzig, Germany, 6 Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany

This study presents first high resolution MRE of intracranial tumors. The reconstructed MRE parameters |G*| and φ correspond to the magnitude and phase of the complex shear modulus G* and therewith provide a measure of the tumor's viscoelastic properties as encountered by surgeons during interventions. The resolution in |G*| and φ maps is superior to previous work enabling us for the first time to analyze the intrinsic viscoelastic heterogeneities of glioblastoma multiforme (GBM). Interestingly, in 4 out of 17 cases GBM was stiffer than healthy tissue while reduction in φ was seen in all tumors suggesting less dissipative GBM properties.

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