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Abstract #1861

Validation of oxygenation and perfusion sensitive MRI methods in healthy brain and brain tumor in mice by invasive micro probe measurements.

Jan Sedlacik 1 , Matthias Reitz 2 , Nils O Schmidt 2 , and Jens Fiehler 1

1 Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany, 2 Neurosurgery, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

Non-invasive assessment of (patho-) physiological parameters, such as perfusion, oxygenation and oxygen metabolism is of great importance for the characterization of pathologies, e.g. tumors, which may be helpful to better predict treatment response and potential outcome. MRI methods sensitive to blood oxygenation and perfusion were validated in healthy mice brain and mice with brain tumors by subsequent invasive micro probe measurements during different free breathing conditions (air, air+10% CO2 and 100% O2).

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