The influence of carbon dioxide on brain functional homotopy using resting-state fMRI
Olga Marshall 1 , Jinsoo Uh 2 , Daniel Lurie 3 , Hanzhang Lu 2 , Michael P. Milham 3,4 , and Yulin Ge 1
1Radiology/Center for Biomedical Imaging,
New York University School of Medicine, New York, NY,
Imaging Research Center, University of Texas
Southwestern Medical Center, Texas, United States,
Mind Institute, New York, United States,
S Kline Institute for Psychiatric Research, New York,
Resting state functional MRI (RS-fMRI) using blood
oxygenation level dependent (BOLD) technique is used to
evaluate the functional connectivity of the human brain.
Brain homotopy (inter-hemispheric coordination) is a
fundamental characteristic of the intrinsic functional
architecture, which now can be assessed with RS-fMRI.
Regional homogeneity (Reho) is another brain
characteristic and RS-fMRI measure for local brain
synchronization. In this study, we have evaluated how
CO2 breathing can influence brain functional homotopy
and Reho in healthy brains at rest in order to better
understand the physiologic respiratory challenge on
global inter-hemispheric and local neighboring neurons
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