Abstract #1825
Mapping the dynamic relationship between cerebral blood flow and BOLD fluctuations: Implications for quantitative fMRI
Aaron Benjamin Simon 1 and Richard Buxton 2
1
Bioengineering, University of California San
Diego, La Jolla, CA, United States,
2
Radiology,
University of California San Diego, La Jolla, CA, United
States
In this work we measured the blood flow and BOLD
responses to visual stimuli, the strength of which were
varied sinusoidally at several temporal frequencies. Our
goal was to determine whether the function that mapped
flow to BOLD responses was unique, or whether it
depended on the frequency or phase of the stimulus. We
found that the mapping from flow to BOLD had little
dependence on the stimulus frequency or phase but that
the mapping function was not unique between stimulus on
and off periods, suggesting that slow changes in volume
or metabolism may complicate the dynamic flow-BOLD
relationship.
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