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Abstract #1827

BOLD Evoked Response during Hyperbaric conditions

Damon P Cardenas 1,2 , Eric Muir 1,2 , Shiliang huang 2 , and Timothy Duong 1,2

1 Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 MRI, Research Imaging Institute, San Antonio, Texas, United States

There are substantial interests in the effects of basal oxygen saturation on BOLD fMRI responses. We evaluated forepaw-evoked BOLD responses in rats under i) normobaric air, ii) normobaric oxygen, iii) 3 atmospheres hyperbaric air, and iv) 3 atmospheres hyperbaric oxygen (HBO). Robust and strong BOLD responses were detected under HBO similar to normobaric air condition, suggesting that there is room to increase total hemoglobin saturation or that other signal mechnisms are involved during HBO.

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