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Abstract #1166

Monte Carlo Simulation of the Effect of Fat Spatial Distribution in Trabecular Bone Marrow on the DDIF MR Signal

Sara Maria Sprinkhuizen 1 , Jerome Ackerman 1 , and Yi-Qiao Song 1,2

1 MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Schlumberger-Doll Research, Cambridge, MA, United States

Decay due to Diffusion in the Internal Field (DDIF) MRI measures solid trabecular bone structures. Bone marrow plays an important role in DDIF MRI: the magnetic susceptibility of marrow fat induces field gradients in the pore spaces which depend on the water-fat ratio and spatial distribution of the fat cells within the pores. In this work we assessed whether DDIF MRI technique may be used to detect bone marrow alterations and diseases. As a first step towards this goal, we simulated the effect of the spatial distribution of marrow fat cells on the DDIF MRI signal for 3 clinical cases.

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