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Abstract #1165

Assessment of the tumoral microenvironment in the development of a glioblastoma rat model by in vivo MRI and ex vivo HRMAS

Ana Amor-Lpez 1 , Roco Prez-Carro 1 , and Pilar Lpez-Larrubia 1

1 Instituto de Investigaciones Biomdicas "Alberto Sols", CSIC-UAM, Madrid, Madrid, Spain

Current techniques for evaluating microvasculature and inflammatory processes linked to cancer development, do not achieve an enough spatial and functional resolution, bordering the applications both for diagnosis and therapy validation. Magnetic resonance imaging and spectroscopy approaches offer a great potential to solving these limitations. In fact, MR approaches allow determining important characteristics of tumor microenvironment as microvascular abnormalities, tumor metabolism, oxygenation level and extracellular-pH between others. This research was focussed on the identification of MR parameters that may act as in vivo surrogate markers of biological characteristic -like inflammation, edema and BBB integrity- of a glioblastoma in a rat model.

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