Abstract #1165
Assessment of the tumoral microenvironment in the development of a glioblastoma rat model by in vivo MRI and ex vivo HRMAS
Ana Amor-Lpez 1 , Roco Prez-Carro 1 , and Pilar Lpez-Larrubia 1
1
Instituto de Investigaciones Biomdicas
"Alberto Sols", CSIC-UAM, Madrid, Madrid, Spain
Current techniques for evaluating microvasculature and
inflammatory processes linked to cancer development, do
not achieve an enough spatial and functional resolution,
bordering the applications both for diagnosis and
therapy validation. Magnetic resonance imaging and
spectroscopy approaches offer a great potential to
solving these limitations. In fact, MR approaches allow
determining important characteristics of tumor
microenvironment as microvascular abnormalities, tumor
metabolism, oxygenation level and extracellular-pH
between others. This research was focussed on the
identification of MR parameters that may act as in vivo
surrogate markers of biological characteristic -like
inflammation, edema and BBB integrity- of a glioblastoma
in a rat model.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
