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Abstract #1164

A Novel Gd-Sucrose Scaffold for Oral Administration in MR-colonography at 7 T

Parastou Foroutan 1 , Gary V Martinez 1 , Valerie E Moberg 1 , Suryakiran Navath 2 , Robert J Gillies 1 , Eugene A Mash 2 , and David L Morse 1

1 Cancer Imaging & Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States, 2 Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States

Colorectal cancer (CRC) is the second leading cause of death in the United States and although CRC prognosis relies on early-stage-disease detection, the standard screening method, colonoscopy, suffers from patient non-compliance. Magnetic resonance colonography (MR-C) is a non-invasive approach that provides excellent soft tissue contrast and 3D datasets without radiation exposure. Herein, we present the development of targeted contrast agents for pre-screening of CRC by 7 T MRI. Specifically, a non-toxic Gd-DOTA sucrose based scaffold for oral administration that can be conjugated to targeting moieties specific for CRC was developed and evaluated in phantoms as well as in vivo in xenografts.

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