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Abstract #1167

Reproducibility of In Vivo Bound and Pore Water Imaging of Cortical Bone

Mary Kate Manhard 1,2 , Robert Adam Horch 2,3 , Daniel F Gochberg 2,3 , Jeffry S Nyman 4 , and Mark D Does 1,2

1 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 4 Department of Orthopaedics & Rehab, Vanderbilt University, Nashville, TN, United States

The previously proposed DAFP and AIR sequences were applied to in vivo clinical scans on three human subjects on the wrist and the lower leg. Bound and pore water concentration maps were obtained from the images on cortical bone of the radius and tibia. Each scan was repeated three times and the reproducibility was investigated as the inter-scan variability. Good repeatability was found (≈10% standard error per ROI), verifying these methods as diagnostic tools for assessing bone quality.

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