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Abstract #1157

Longitudinal Generalized Q-Sampling MRI Evaluation in Rabbit Brain after Cerebral Hemisphere Radiation Exposure

Chao-Yu Shen 1,2 , Fang-Yu Nien 1 , Zhen-Hui Li 1 , Yeu-Sheng Tyan 1,2 , and Jun-Cheng Weng 1,2

1 School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2 Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Radiation therapy is widely used for the treatment of both primary and metastatic brain tumors and can lead to cellular, vascular and axonal injury and further behavioral deficits. Imaging assessment of the brain damage caused by radiation therapy is very important for determining patient prognoses. Previously we used diffusion tensor imaging (DTI) and T2-weighted imaging (T2WI) to evaluate post-irradiation brain injury. To improve evaluation of the neuro-toxic adverse effects of irradiation treatment in both gray and white matter structures, in this study we longitudinally evaluated the changes in various brain compartments on a clinical MR scanner by using generalized q-sampling imaging (GQI) indices mappings, generalized fractional anisotropy (GFA), quantitative anisotropy (QA) and isotropic value (ISO) of the orientation distribution function (ODF), for single sub-lethal high dose (30 Gy) cerebral hemisphere exposure radiation-induced brain injury on adult rabbit model.

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