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Abstract #1158

Exploring the Biomechanical Properties of Brain Malignancies and their Pathological Determinants with Magnetic Resonance Elastography

Jin Li 1 , Yann Jamin 1 , Jessica K.R. Boult 1 , Philippe Garteiser 2 , Jose L. Ulloa 3 , Sergey Popov 4,5 , Craig Cummings 1 , Gary Box 5 , Suzanne A. Eccles 5 , Chris Jones 4,5 , John C. Waterton 3 , Jeffrey C. Bamber 1 , Ralph Sinkus 2,6 , and Simon P. Robinson 1

1 Division of Radiotherapy & Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 INSERM U773, CRB3, Centre de Recherches Biomdicales Bichat-Beaujon, France, 3 Personalised Healthcare and Biomarkers, AstraZeneca, Macclesfield, Cheshire, United Kingdom, 4 Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 5 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 6 BHF Centre of Excellence, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St Thomas' Hospital, London, United Kingdom

Recently MRE revealed that tumours derived from human breast adenocarcinoma MDA-MB-231, rat Glioma RG2 or human gioblastoma U87-MG cells were softer than healthy brain tissue, with MDA-MB-231 significantly softer and less viscous than the other two models. We investigated the cellular density, microvessel density, myelin content and collagen content in these models, and showed that between the tumours, in MDA-MB-231 tumours, cell density and microvessel density were significantly lower than the other two models, positive correlated with MRE-derived elasticity and viscosity. Meanwhile, the lack of anisotropic structure of intracranial tumours may underpin their relative softness.

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