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Abstract #1156

Identification of Early Stage Glioblastoma Multiform in Rats by Multi-parametric MR Imaging Techniques: Preliminary Results

Xu Han 1,2 , Hua Guo 2 , Le He 2 , Xiaodong Ma 2 , Tingting Ha 3 , Kai Wang 4 , Yanfeng Xu 5 , Jianming Cai 1 , and Xihai Zhao 2

1 Department of Radiology, Chinese PLA general hospital, Beijing, China, 2 Center for Biomedical Imaging Research & Department of Biomedical Engineering, Tsinghua University, Beijing, China, 3 Department of Radiology, Tiantan hospital, Capital Medical University, Beijing, China, 4 Imaging Center of Neuroscience, Tiantan Hospital, Capital Medical University, Beijing, China, 5 Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing, China

In this study, the preliminary results indicate that the multi-parametric MR imaging technique is feasible to identify the GBM in rats at early stage. Compared to the traditional imaging sequences, each sequence of our multi-parametric imaging protocol, such as spiral DWI, VDS-DWI, DCE-MRI and CE-T1W, enables discrimination of the early stage GBM from post-injury brain edema. For VDS-DWI, the increase of SNR and removal of distortion can be also obtained in GBM animal model in our study. The multi-parametric imaging techniques might be an alternative imaging approach to detect lesions no matter in brain or other organs at clinically.

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