Abstract #1156
Identification of Early Stage Glioblastoma Multiform in Rats by Multi-parametric MR Imaging Techniques: Preliminary Results
Xu Han 1,2 , Hua Guo 2 , Le He 2 , Xiaodong Ma 2 , Tingting Ha 3 , Kai Wang 4 , Yanfeng Xu 5 , Jianming Cai 1 , and Xihai Zhao 2
1
Department of Radiology, Chinese PLA general
hospital, Beijing, China,
2
Center
for Biomedical Imaging Research & Department of
Biomedical Engineering, Tsinghua University, Beijing,
China,
3
Department
of Radiology, Tiantan hospital, Capital Medical
University, Beijing, China,
4
Imaging
Center of Neuroscience, Tiantan Hospital, Capital
Medical University, Beijing, China,
5
Institute
of Laboratory Animal Sciences, Chinese Academy of
Medical Sciences, Beijing, China
In this study, the preliminary results indicate that the
multi-parametric MR imaging technique is feasible to
identify the GBM in rats at early stage. Compared to the
traditional imaging sequences, each sequence of our
multi-parametric imaging protocol, such as spiral DWI,
VDS-DWI, DCE-MRI and CE-T1W, enables discrimination of
the early stage GBM from post-injury brain edema. For
VDS-DWI, the increase of SNR and removal of distortion
can be also obtained in GBM animal model in our study.
The multi-parametric imaging techniques might be an
alternative imaging approach to detect lesions no matter
in brain or other organs at clinically.
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