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Abstract #1155

A feasibility study of diffusion MRI for early detection of xenograft models in mice.

Paola Porcari 1,2 , Monika E Hegi 3 , Hongxia Lei 1 , Marie-France Hamou 3 , Irene Vassallo 3 , Silvia Capuani 4,5 , Rolf Gruetter 1,6 , and Vladimir Mlynarik 1,7

1 Center for Biomedical Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 2 Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 3 Clinical Neurosciences, Laboratory of Brain Tumor Biology and Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 4 CNR-IPCF UOS Roma Sapienza, Physics Department, Sapienza University of Rome, Rome, Italy, 5 Center for Life Nanoscience@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy, 6 Departments of Radiology, Universities of Lausanne and Geneva, Switzerland, 7 High Field MR Center, Medical University of Vienna, Vienna, Austria

In this study, high sensitivity and specificity of diffusion MRI methods for early detection of slow growing and highly infiltrative tumours, otherwise not visible in conventional T2-weighted images, haves been demonstrated. In contrast to conventional MRI, tumours grown as human glioma sphere xenografts in mice were identified and investigated in the early stages, and confirmed by proton MR spectroscopy and immunohistochemistry. Differences in diffusion properties of each xenograft highlighted diverse tumour microstructures which were notably reflected by histology.

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