Abstract #1155
A feasibility study of diffusion MRI for early detection of xenograft models in mice.
Paola Porcari 1,2 , Monika E Hegi 3 , Hongxia Lei 1 , Marie-France Hamou 3 , Irene Vassallo 3 , Silvia Capuani 4,5 , Rolf Gruetter 1,6 , and Vladimir Mlynarik 1,7
1
Center for Biomedical Imaging, Ecole
Polytechnique Fdrale de Lausanne, Lausanne,
Switzerland,
2
Newcastle
Magnetic Resonance Centre, Newcastle University,
Newcastle upon Tyne, United Kingdom,
3
Clinical
Neurosciences, Laboratory of Brain Tumor Biology and
Genetics, Lausanne University Hospital and University of
Lausanne, Lausanne, Switzerland,
4
CNR-IPCF
UOS Roma Sapienza, Physics Department, Sapienza
University of Rome, Rome, Italy,
5
Center
for Life Nanoscience@Sapienza, Istituto Italiano di
Tecnologia, Rome, Italy,
6
Departments
of Radiology, Universities of Lausanne and Geneva,
Switzerland,
7
High
Field MR Center, Medical University of Vienna, Vienna,
Austria
In this study, high sensitivity and specificity of
diffusion MRI methods for early detection of slow
growing and highly infiltrative tumours, otherwise not
visible in conventional T2-weighted images, haves been
demonstrated. In contrast to conventional MRI, tumours
grown as human glioma sphere xenografts in mice were
identified and investigated in the early stages, and
confirmed by proton MR spectroscopy and
immunohistochemistry. Differences in diffusion
properties of each xenograft highlighted diverse tumour
microstructures which were notably reflected by
histology.
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