Abstract #1129
Toward Distinguishing Radiation Effects from Tumor Regrowth in an Irradiated Glioma Model
Carlos J Perez-Torres 1 , John A Engelbach 1 , Jeremy Cates 2 , Dinesh K Thotala 2 , Robert E Drzymala 2 , Joseph JH Ackerman 1,3 , and Joel R Garbow 1
1
Department of Radiology, Washington
University, Saint Louis, MO, United States,
2
Department
of Radiation Oncology, Washington University, Saint
Louis, MO, United States,
3
Department
of Chemistry, Washington University, Saint Louis, MO,
United States
A major unmet challenge in the treatment of brain tumors
is non-invasively differentiating recurrent tumor from
delayed radiation injury. Our work focused on the
difference in cellularity between tumor and radiation
injury via Diffusion Weighted Imaging (DWI) and
Magnetization Transfer Contrast (MTC) MRI. Our results
in preclinical rodent models suggest that DWI may help
discriminate between tumor and radiation effects while
MTC, though sensitive , is mostly incapable of
differentiating between tumor and radiation effects.
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