Abstract #1128
Monitoring tumor response to the direct or indirect targeting of choline
Lionel Mignion 1 , Pierre Danhier 1 , Paolo E. Porporato 2 , Julie Magat 1 , Pierre Sonveaux 2 , Vincent Gregoire 3 , Bernard Gallez 1 , and Benedicte F. Jordan 1
1
Biomedical Magnetic Resonance Unit, Louvain
Drug Research Institute, Universit Catholique de
Louvain, Brussels, Belgium,
2
Pole
of pharmacology, Institut de Recherche Exprimentale et
Clinique, Universit Catholique de Louvain, Brussels,
Belgium,
3
Pole
of Molecular Imaging, Radiotherapy and Oncology,
Universit Catholique de Louvain, Brussels, Belgium
The aim of the current study is to assess response to
the modulation of the choline pathway, that is known to
be involved in oncogenesis, by using specific choline
kinase and transporters inhibitors and shRNA of choline
kinase. In this work we proposed a combination of
choline spectroscopy and diffusion markers to predict
the tumor evolution after treatment. Using these
combined markers we can assess the actual inhibition of
the target in vivo and assess early tumor response non
invasively, in order to avoid drug resistance with the
ultimate goal of improving therapy individualization.
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