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Abstract #1127

Towards MRI-based measurement of tissue oxygen content

Scott C. Beeman 1 , John A. Engelbach 1 , Joseph J.H. Ackerman 1,2 , and Joel R. Garbow 1

1 Department of Radiology, Washington University in Saint Louis, Saint Louis, Missouri, United States, 2 Department of Chemistry, Washington University in Saint Louis, Saint Louis, Missouri, United States

We, and others, are pursuing a technique to measure tissue oxygenation that takes advantage of the paramagnetic property of molecular oxygen, as found dissolved in tissue. Herein, we present a R 1 -based breathing gas challenge technique that can distinguish radiation damage from tumor - a distinction which has been difficult to make using other methods. We further show that the R 1 of brain parenchyma can be measured by isolating the R 1 of bulk water and suppressing flow contributions, and that breathing of carbogen gas has a direct impact on the R 1 of brain parenchyma.

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