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Abstract #1130

Adaptive Therapy: A Novel Cancer Treatment Regimen Using MRI.

Pedro M Enriquez-Navas 1 , Tuhin Das 1 , Yoonseok Kam 1 , Parastou Foruotan 1 , Gary Martinez 1 , Robert J Gillies 1 , and Robert A Gatenby 2

1 Cancer Imaging and Metabolism, Moffitt Cancer Center, Tampa, Florida, United States, 2 Radiology, Moffitt Cancer Center, Tampa, Florida, United States

Cancer is treated with the highest possible dose of drug, depending on toxicity, to achieve the maximum drug effect. However, this is a flawed approach because of the evolutionary dynamics that depend on the variable fitness across the tumor. Thus, the treatment scheduling is suboptimal. Adaptive therapy (AT) is a novel cancer therapy. The dose is dependent on the tumor status. The key point is that AT has been demonstrated to promote the growth of chemosensitive tumor cells at the expense of chemoresistant ones. With the focus on translation, we are applying MRI tools to fine tune AT in vivo.

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