Abstract #1115
Steady-state susceptibility contrast MRI detects early anti-angiogenic effects of a novel biomimetic peptide in a human breast cancer model
Eugene Kim 1 , Esak Lee 1 , Charlesa Plummer 2 , Stacy Gil 1 , Alexander S Popel 1 , and Arvind P Pathak 2
1
Department of Biomedical Engineering, Johns
Hopkins University School of Medicine, Baltimore, MD,
United States,
2
Department
of Radiology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Steady-state susceptibility contrast (SSC)-MRI is a
clinically translatable technique that is used to
measure vascular morphology. We show here that a novel
biomimetic peptide we developed produced strong anti-angiogenic
effects in an orthotopic human breast cancer model. SSC-MRI
was able to detect treatment-induced decreases in blood
volume and vessel caliber before the manifestation of
significant differences in tumor growth and cellularity
(conventional markers of therapeutic efficacy) between
treated and control groups. This suggests that SSC-MRI
provides promising biomarkers of early anti-angiogenic
treatment response that may improve the evaluation and
development of new anti-angiogenic therapies.
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