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Abstract #1115

Steady-state susceptibility contrast MRI detects early anti-angiogenic effects of a novel biomimetic peptide in a human breast cancer model

Eugene Kim 1 , Esak Lee 1 , Charlesa Plummer 2 , Stacy Gil 1 , Alexander S Popel 1 , and Arvind P Pathak 2

1 Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Steady-state susceptibility contrast (SSC)-MRI is a clinically translatable technique that is used to measure vascular morphology. We show here that a novel biomimetic peptide we developed produced strong anti-angiogenic effects in an orthotopic human breast cancer model. SSC-MRI was able to detect treatment-induced decreases in blood volume and vessel caliber before the manifestation of significant differences in tumor growth and cellularity (conventional markers of therapeutic efficacy) between treated and control groups. This suggests that SSC-MRI provides promising biomarkers of early anti-angiogenic treatment response that may improve the evaluation and development of new anti-angiogenic therapies.

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