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Abstract #1114

Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decreases breast cancer cell proliferation and invasion

Maria Dung Cao 1,2 , Menglin Cheng 2 , Lu Jiang 2 , Tiffany R Greenwood 2 , Balaji Krishnamachary 2 , Zaver M Bhujwalla 2 , Tone F Bathen 1 , and Kristine Glunde 2,3

1 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, 2 Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 3 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Here we investigated the effects of targeting choline phospholipid metabolism using GDPD5 and GDPD6 siRNA in two breast cancer cell lines, MCF7 and MDA-MB-231. Our study shows that GDPD5 and GDPD6 siRNA treatment increases glycerophosphocholine levels, decreases proliferation and invasion, but did not cause apoptosis. The effect of GDPD5 siRNA on cell proliferation was more severe in the less malignant breast cancer cell line. Decreased cell invasion was observed in GDPD5 compared to GDPD6 siRNA treated cells. Our results suggest that GDPD5 and GDPD6 silencing alone/combined can have a potential role as new molecular targets for treatment of breast cancer.

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