Abstract #1114
Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decreases breast cancer cell proliferation and invasion
Maria Dung Cao 1,2 , Menglin Cheng 2 , Lu Jiang 2 , Tiffany R Greenwood 2 , Balaji Krishnamachary 2 , Zaver M Bhujwalla 2 , Tone F Bathen 1 , and Kristine Glunde 2,3
1
Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology
(NTNU), Trondheim, Norway,
2
Department
of Radiology and Radiological Science, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
3
Sidney
Kimmel Comprehensive Cancer Center, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States
Here we investigated the effects of targeting choline
phospholipid metabolism using GDPD5 and GDPD6 siRNA in
two breast cancer cell lines, MCF7 and MDA-MB-231. Our
study shows that GDPD5 and GDPD6 siRNA treatment
increases glycerophosphocholine levels, decreases
proliferation and invasion, but did not cause apoptosis.
The effect of GDPD5 siRNA on cell proliferation was more
severe in the less malignant breast cancer cell line.
Decreased cell invasion was observed in GDPD5 compared
to GDPD6 siRNA treated cells. Our results suggest that
GDPD5 and GDPD6 silencing alone/combined can have a
potential role as new molecular targets for treatment of
breast cancer.
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