Monitoring therapeutic effect of a vascular disrupting agent: correlation between perfusion parameters derived from intravoxel incoherent motion diffusion-weighted imaging and dynamic contrast enhanced MRI

Dynamic contrast enhanced (DCE) MRI has been widely used for noninvasive assessment of the change in tumor perfusion. Recently, intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) by using a bi-exponential fitting of the DWI data from multiple b-values has been reported to be useful for quantitative measurement of tumor perfusion without requirement of contrast medium. Our study using a rabbit liver tumor model demonstrated significant correlation between serially measured perfusion parameters derived from IVIM-DWI and DCE-MRI in the vascular disrupting agent (VDA)-treated group. Therefore, IVIM-DWI may be a useful surrogate of DCE-MRI in the longitudinal monitoring therapeutic effect of VDAs.

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