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Abstract #1112

T 1ρ Mapping for the Evaluation of High Intensity Focused Ultrasound Tumor Treatment

Stefanie JCG Hectors 1,2 , Rik PM Moonen 1,2 , Gustav J Strijkers 1,2 , and Klaas Nicolay 1,2

1 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Center for Imaging Research and Education, Eindhoven, Netherlands

This study was aimed to assess the effects of HIFU treatment on tumor T . T measurements at various spin-lock amplitudes (0-2000 Hz) were performed before, directly after and 3 days after HIFU treatment of murine tumors. The tumor T at spin-lock amplitudes higher than or equal to 100 Hz significantly decreased at 3 days after HIFU compared to pre-treatment. The T decline after HIFU became significantly larger with increasing spin-lock amplitudes, indicative of increased contrast between HIFU-treated and non-treated tissue at higher spin-lock amplitudes. Altogether, the data suggest that T is a suitable biomarker for the evaluation of HIFU treatment.

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