Abstract #1116
Changes in tumor perfusion and oxygenation following CA4P administration
Florence Colliez 1 , Anne-Catherine Fruytier 1 , Marie-Aline Neveu 1 , Julie Magat 1 , Bernard Gallez 1 , and Bndicte F Jordan 1
1
Louvain Drug Research Institute, Biomedical
Magnetic Resonance Research Group, University of
Louvain, Brussels, Belgium
Vascular discrupting agents (VDAs) induce tumor hypoxia
within 3 hours in preclinical models. Combretastatin A4
phosphate (CA4P) is the lead compound of this agents
class. The present work correlates a follow-up on two
tumor models of both tumor oxygenation and tumor
hemodynamics after CA4P administration. Mapping of tumor
oxygenation was assessed with MOBILE (Mapping of
Oxygen By Imaging Lipids relaxation Enhancement) a
non-invasive MRI method based on the changes in the
relaxation properties of the tissue lipids protons
whereas tumor hemodynamics (Ktrans and vp) variations
were evaluated by DCE-MRI on same tumor models.
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