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Abstract #1108

Repeatability of geometrically corrected DWI scans for treatment response monitoring in oesophageal cancer

Astrid L.H.M.W. van Lier 1 , Peter S.N. van Rossum 1,2 , Gert J. Meijer 1 , Cornelis A.T. van den Berg 1 , Marille E.P. Philippens 1 , Jan J.W. Lagendijk 1 , Marco van Vulpen 1 , and Irene M. Lips 1

1 Radiotherapy, UMC Utrecht, Utrecht, Utrecht, Netherlands, 2 Surgery, UMC Utrecht, Utrecht, Utrecht, Netherlands

Prior to constructing a model for DWI-based response prediction in esophageal cancer, we investigated the repeatability of the ADC determination in the tumor. As the DWI images are geometrically distorted, we opted for retrospective correction of the maps prior to analysis. The coefficient of repeatability was found to be 11.0% (Bland-Altman analysis). No significant correlation was found between the ADC repeatability error and mean pixel shift. The repeatability error was generally smaller than the pre-per and pre-post treatment ADC difference (8/11 cases). We will continue to use the proposed DWI protocol for development of a treatment response prediction model.

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