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Abstract #1109

ADC histogram analysis: investigation of treatment response and survival in advanced ovarian cancer

Andrew Nicholas Priest 1 , Andrew J Patterson 1 , Masako Y Kataoka 1 , Ilse Joubert 1 , Mary A McLean 2 , Martin John Graves 1 , Charlotte Hodgkin 2 , Robin A Crawford 3 , Helena M Earl 3 , John R Griffiths 2 , James D Brenton 2,3 , David John Lomas 1 , and Evis Sala 1

1 Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom, 2 Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, 3 Oncology and Gynaecological Oncology, Addenbrooke's Hospital, Cambridge, United Kingdom

Diffusion-weighted imaging was used to assess treatment response in advanced ovarian cancer. Histogram analysis can potentially give more information about heterogeneous tumours than mean values. This study investigated, for both primary ovarian tumours and metastatic disease, how ADC histogram parameters change with neoadjuvant chemotherapy, and their relationships to treatment response and survival. Highly significant changes were found for the primary tumour in responders but not non-responders, with significantly greater changes in responders for the mean, 75th and 90th percentiles. However, no significant differences or changes were found for metastatic lesions. No relationship with survival was found for any lesion.

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