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Abstract #1099

In Vivo Assessment of Non-Small Cell Lung Cancer: Detection of Early Response to Concurrent Chemoradiotherapy by Using Breath-Hold Dynamic Contrast Enhanced MRI

Xiuli Tao 1 , Han Ouyang 1 , Feng Ye 1 , Zihua Su 2 , Xiao Xu 2 , and Ning Wu 1

1 Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2 GE Healthcare, Beijing, China

DCE-MRI has been extensively used in monitoring treatment response on many anatomies. However, this technique was not fully explored in lung cancer due to breathing motion. In this paper, we demonstrated by using a mutual information based nonlinear registration scheme and two compartment Tofts model, clinical relevant parameters could be extracted from a breath-hold DCE-MRI to monitor treatment response on NSCLC.

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