Abstract #1098
Comparison of Patient-Specific and Fixed Arterial Input Functions for Assessing Treatment Response at DCE-MRI
Mihaela Rata 1 , Matthew R Orton 1 , Christina Messiou 1 , Elly Castellano 1 , Helen Young 2 , Nandita de Souza 1 , David J Collins 1 , and Martin O Leach 1
1
CRUK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research & Royal Marsden NHS
Foundation Trust, Sutton, Surrey, United Kingdom,
2
Early
Clinical Development, AstraZeneca, Macclesfield, United
Kingdom
Accurate AIF measurement in DCE-MRI studies is
challenging due to various confounding factors: in
clinical trials looking at treatment response a fixed
AIF is often used. Whilst this removes a major source of
variation, if the treatment affects the AIF, such
changes will be erroneously reflected in the tissue
parameters. This abstract compares the repeatability and
treatment effect of Ktrans obtained using three AIFs:
fixed AIF; AIF from a vessel in the DCE-MRI data; AIF
obtained on the same day with a DC-CT examination. A
fixed AIF is most repeatable, but the DC-CT AIF has a
more significant treatment effect.
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