Abstract #1097
Repeatability of DCE-MRI Parameters in a Paediatric Oncology Population
Neil P Jerome 1 , Keiko Miyazaki 1 , David J Collins 1 , Matthew R Orton 1 , James d'Arcy 1 , Lucas Moreno 2,3 , Andrew D J Pearson 2,3 , Lynley V Marshall 2,3 , Fernando Carcellar 2,3 , Martin O Leach 1 , Stergios Zacharoulis 2,3 , and Dow-Mu Koh 4
1
CR-UK and EPSRC Cancer Imaging Centre, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
Paediatric
Drug Development Team, Cancer Therapeutics and Clinical
Studies, The Institute of Cancer Research, Sutton,
Surrey, United Kingdom,
3
Paediatric
Drug Development Unit, Children and Young People's Unit,
The Royal Marsden NHS Foundation Trust, Sutton, Surrey,
United Kingdom,
4
Department
of Radiology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom
It is essential that functional imaging-derived
biomarkers have acceptable repeatability in order to
have confidence in measured changes. Where paediatric
populations may exhibit varying physiology/metabolism to
adults, there is a need to specifically assess
repeatability of DCE-MRI in a paediatric population. For
a paediatric cohort (median age 11, range 6 15 years)
of five extra- and seven intra-cranial solid tumours,
DCE was performed on two successive days, with analysis
using cohort-derived AIF and extended Tofts model. Both
model-derived and model-independent parameters showed
acceptable repeatability (CV<20%), with native T
1
and
IAUGC60 performing best (CV 6.2 % and 12.8 %
respectively).
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