Abstract #1096
LOCAL VASCULAR INPUT FUNCTION FOR PHARMACOKINETIC MODELING OF PROSTATE CANCER
Hatef Mehrabian 1 , Masoom A. Haider 2 , and Anne L. Martel 1
1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
2
Medical
Imaging, Sunnybrook Health Sciences Centre, Toronto,
Ontario, Canada
A major component in multi-parametric MRI of tumors is
pharmacokinetic modeling of their DCE-MRI which provides
information about perfusion and vascular permeability.
Such analysis requires an AIF that is approximated
outside of the tissue and is a major source of error and
discrepancy among studies. Using a local vascular input
function (VIF) instead has the potential to improve PK
analysis. This paper investigates the effects of using
VIF (in 19 prostate DCE-MRI datasets) and shows more
consistent PK parameters are obtained for normal
peripheral zone tissue compared to using AIF and result
in better separation of tumor and normal tissues.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
