Abstract #1100
The response to chemotherapy of mesothelioma tumours as assessed by dynamic contrast-enhanced MRI: first impressions
Andrew B Gill 1,2 , Andrew N Priest 2 , and Nagmi Qureshi 1
1
Radiology, Papworth Hospital NHS Foundation
Trust, Cambridge, United Kingdom,
2
Medical
Physics, Cambridge University Hospitals, Cambridge,
United Kingdom
Mesothelioma has rarely been the subject of DCE-MRI
investigations. This study applies pharmacokinetic
modeling to DCE-MRI data acquired in patients with
mesothelioma tumours to generate parameters associated
with tumour perfusion (e.g.
K
trans
,
v
p
).
Results from examinations before and after chemotherapy
are reported in this abstract. Initial findings indicate
that changes in
K
trans
may
correlate well with the response to treatment as
evaluated by standard CT RECIST measures. Further
patient numbers are needed to confirm these early
impressions.
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