Abstract #1007
Assessment of Diabetic Skeletal Muscle Metabolism Using Hyperpolarized 13C MR Spectroscopy
Jae Mo Park 1 , Sonal Josan 1 , Ralph Hurd 2 , James Graham 3 , Peter Havel 3 , David Bendahan 4 , Dirk Mayer 5 , Daniel Spielman 1 , and Thomas Jue 6
1
Radiology, Stanford University, Stanford,
CA, United States,
2
GE
Healthcare, Menlo Park, CA, United States,
3
Molecular
Bioscience, UC Davis, Davis, CA, United States,
4
Centre
de Resonance Magnetique Biologique et Medicale,
Marseille, France,
5
Diagnostic
Radiology and Nuclear Medicine, University of Maryland,
MD, United States,
6
Biochemistry,
UC Davis, Davis, CA, United States
We performed in vivo experiments to assess the oxidative
pathway contribution in the type 2 diabete mellitus
(T2DM) model using hyperpolarized [1-13C]lactate and
[2-13C]pyruvate. The metabolism of hyperpolarized
[1-13C]lactate in the muscle was different in T2DM as
compared to control rats, in particular with respect to
PDH activity. The restoration of PDH activity with
dichloroacetate in the T2DM rat suggests a
non-negligible contribution of oxidative metabolism
impairment in diabetes and a potential role for PDH
activation to restore glucose homeostasis.
[2-13C]pyruvate experiment suggests that ketogenesis is
more active rather than the oxidative phosphorylation in
diabetic muscle metabolism after dichloroacetate
infusion.
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