Abstract #1008
Variation in Skeletal Muscle and Liver Glycogen Concentration During Normal Daily Eating in Type 2 Diabetes
Fiona Elizabeth Smith 1 , Mavin Macauley 1 , Peter Thelwall 1 , and Roy Taylor 1
1
Institute of Cellular Medicine, Newcastle
University, Newcastle upon Tyne, United Kingdom
Skeletal muscle plays a major role in glucose
homeostasis in normal health. Approximately 30% of meal
carbohydrate is stored as muscle glycogen after the
first meal of the day and rises after subsequent meals.
Liver stores approximately 20% of meal carbohydrate in
healthy subjects. Glycogen depots behave as a dynamic
buffer allowing rapid storage of osmotically active
glucose. However, the effectiveness of this diurnal
mechanism has not been previously studied in Type 2
diabetes. The study aim was to quantify changes in
skeletal muscle and liver glycogen concentration during
normal eating in Type 2 Diabetes comparing this to
healthy subjects.
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