Meeting Banner
Abstract #0980

Enhanced tissue classification of acute ischemic diffusion kurtosis lesion with intrinsic kurtosis heterogeneity correction

Phillip Zhe Sun 1 , Yu Wang 1 , Emiri Mandeville 2 , Mark Vangel 1 , Eng Lo 2 , and Xunming Ji 3

1 Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, MA, United States, 3 Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China

Recent studies have shown that mean kurtosis (MK) can stratify irreversibly damaged ischemic DWI lesion. However, the kurtosis map is heterogeneous due to complex cerebral structure and composition, reducing its specificity to ischemia. We evaluated the correlation between MK, diffusivity (MD), fractional anisotropy (FA) and relaxation, and found significant correlation between MK and R1 (P<0.001). Using an animal stroke model, we demonstrated that relaxation-normalized kurtosis MRI significantly enhanced tissue segmentation of ischemic kurtosis lesion over the standard MK map. We also found significant diffusion/kurtosis lesion mismatch, with MK and MD lesion volumes measuring 17278 and 20693 mm3, respectively.

This abstract and the presentation materials are available to members only; a login is required.

Join Here