Meeting Banner
Abstract #0981

Simultaneous multi-slice imaging of multiple metabolites using spectral-spatial excitation for hyperpolarized 13C experiments

Angus Z. Lau 1,2 , William Dominguez-Viqueira 3 , Albert P. Chen 4 , Charles H. Cunningham 3,5 , Matthew D. Robson 1 , and Damian J. Tyler 1,2

1 Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2 Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom, 3 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4 GE Healthcare, Toronto, ON, Canada, 5 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

DNP-dissolution MRI is a novel method for imaging in vivo metabolism in real-time. Spectral-spatial excitation can be used to obtain full 3D volumes rapidly in a multi-slice mode, but for substrates with many downstream metabolites or multiple polarized substrates, excitation of metabolic resonances one at a time becomes challenging due to limited available scan time. In this abstract, we combine simultaneous multi-slice (SMS) acceleration with spectral-spatial excitation. We demonstrate the method in a water/acetone phantom (7-fold acceleration) and in retrospectively aliased 13C cardiac images (2-fold acceleration). We anticipate the scan time reduction will enable new applications in hyperpolarized 13C MRI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here