Abstract #0979
Evaluation of Diffusion Kurtosis Imaging in Hypomyelinated Mouse Models
Nathaniel D Kelm 1,2 , Kathryn L West 1,2 , Daniel F Gochberg 2,3 , Robert P Carson 4,5 , Kevin C Ess 4,5 , and Mark D Does 1,2
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Institute
of Imaging Science, Vanderbilt University, Nashville,
TN, United States,
3
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
4
Neurology,
Vanderbilt University, Nashville, TN, United States,
5
Pediatrics,
Vanderbilt University, Nashville, TN, United States
Diffusion kurtosis imaging (DKI) is an extension of DTI
with the potential of providing additional information
about white matter microstructure and its state of
myelination. DKI measures are compared with
myelin-related measures, myelin water fraction (MWF) and
macromolecular pool size ratio (PSR), in order to assess
the utility of DKI in the characterization of myelin.
DKI parameters mean kurtosis (MK) and radial kurtosis (RK)
showed stronger correlations with MWF and PSR compared
to conventional DTI parameters, indicating the potential
of DKI for assessment of myelination.
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