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Abstract #0978

Resolving multiple fiber crossings with high b -value and high angular resolution q -ball imaging

Aapo Nummenmaa 1 , Thomas Witzel 1 , Ville Renvall 1,2 , Bruce R Rosen 1 , Van J Wedeen 1 , and Lawrence L Wald 1

1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States, 2 Brain Research Unit, O.V. Lounasmaa Laboratory, Aalto University, Espoo, Finland

We study the effect of using high diffusion weighting ( b -value) and high angular resolution diffusion imaging in resolving multiple intravoxel crossing fiber populations. Three q -ball diffusion-sampling scenarios are considered: b -value of 5000 s/mm 2 with 128 diffusion sampling gradient directions and b -value of 10000 s/mm 2 with 128 and 256 directions. The spherical harmonics expansion method is used to reconstruct the diffusion orientation distribution functions (ODFs). The results show that increasing b -value and angular resolution increases the sharpness of the ODF as well as the amplitude of the subdominant fiber population, indicating a more accurate delineation of the intravoxel fiber crossing.

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