Abstract #0978
Resolving multiple fiber crossings with high b -value and high angular resolution q -ball imaging
Aapo Nummenmaa 1 , Thomas Witzel 1 , Ville Renvall 1,2 , Bruce R Rosen 1 , Van J Wedeen 1 , and Lawrence L Wald 1
1
Athinoula A. Martinos Center for Biomedical
Imaging, Department of Radiology, Massachusetts General
Hospital, Harvard Medical School, Boston, Massachusetts,
United States,
2
Brain
Research Unit, O.V. Lounasmaa Laboratory, Aalto
University, Espoo, Finland
We study the effect of using high diffusion weighting (
b
-value)
and high angular resolution diffusion imaging in
resolving multiple intravoxel crossing fiber
populations. Three
q
-ball
diffusion-sampling scenarios are considered:
b
-value
of 5000 s/mm
2
with
128 diffusion sampling gradient directions and
b
-value
of 10000 s/mm
2
with
128 and 256 directions. The spherical harmonics
expansion method is used to reconstruct the diffusion
orientation distribution functions (ODFs). The results
show that increasing
b
-value
and angular resolution increases the sharpness of the
ODF as well as the amplitude of the subdominant fiber
population, indicating a more accurate delineation of
the intravoxel fiber crossing.
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