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Abstract #0916

MRI Evaluation of a Peptide-Coated Nanoparticle as a Potential Therapy Against Preclinical Brain Metastatic Breast Cancer

Amanda M Hamilton 1 , Sallouha Aidoudi-Ahmed 2 , Venkata R Kotamraju 2 , Shweta Sharma 2 , Paula J Foster 1 , Kazuki N Sugahara 2 , Erkki Ruoslahti 2 , and Brian K Rutt 3

1 Robarts Research Institute, London, Ontario, Canada, 2 Sanford-Burnham Medical Research Institute, California, United States, 3 Stanford University, California, United States

MRI was used to evaluate the treatment efficacy of iRGD-NW, a magnetic nanoparticle coated with a tumor-penetrating peptide in a preclinical breast cancer brain metastasis model. Mice received saline, iRGD-NW (tumor-homing) or CRGDC-NW at day (td) 6 or 12 post-cell injection. Tumor formation was evaluated by MRI at two time points after treatment administration. Td6 iRGD-NW mice displayed significantly lower tumor burden and signal void retention than that of saline mice. There was no observed treatment effect for td12 mice. Results showed that iRGD-NW had a significant time-dependent effect on tumor burden and suggest a potential use in metastasis prevention.

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