Abstract #0915
Imaging biomarkers of cell death: a comparison between viscoelasticity and ADC in an orthotopic breast cancer xenograft model
Jin Li 1 , Yann Jamin 1 , Jessica K.R. Boult 1 , John C. Waterton 2 , Ralph Sinkus 3 , Michelle D. Garrett 4 , and Simon P. Robinson 1
1
Division of Radiotherapy & Imaging, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
Personalised
Healthcare and Biomarkers, AstraZeneca, Macclesfield,
Cheshire, United Kingdom,
3
BHF
Centre of Excellence, Division of Imaging Sciences and
Biomedical Engineering, King's College London, King's
Health Partners, St Thomas' Hospital, London, United
Kingdom,
4
Division
of Cancer Therapeutics, The Institute of Cancer
Research, Sutton, Surrey, United Kingdom
Comparison of MRE-derived imaging biomarkers of
viscoelasticity (|G*|) and ADC in orthotopically
propagated BT474 breast cancer xenografts revealed a
close spatial association and quantitative correlation
of reduced |G*| and elevated ADC with
pathologically-confirmed cell death. A stronger and more
significant correlation between |G*| and cell death
supports |G*| as a potentially more sensitive biomarker
of cell death than ADC.
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